Wednesday, March 5, 2008

Temporary short duration fillers (Part II of IV)

Temporary short duration fillers (3- 8 months)

The collagen fillers are from another specie of animal (Zyderm, Zyplast, Resoplast, Fibril) last for 6-12 months but are no longer in favor since they require skin testing first and although they are fine for deep facial wrinkles.
Human collagen (Cosmoplast, Cosmoderm) is derived from fibroblast cell cultures and is less lumpy then Zyderm and Zyplast. Cosmoderm is used for fine lines such as crow’s feet and to fill in the shallow wrinkles around the lip line. Cosmoderm is a more viscous formula and used in the treatment of deeper lines and furrows as well as lip “plumping”. As Cosmoplast does treat deeper wrinkles, it also includes lidocaine, a local anesthetic, in the formula to minimize discomfort.

Hyaluronic acid (HA) fillers (Restylane, Perlane, Juvederm, Captique) are the most popular fillers used in the US and are produced from a bacteria, Streptococcus equi. HA is a natural substance found in skin and works to trap water and plump skin, thus while you’ll often find it in your everyday moisturizer. HA helps in maintaining volume and shape in your face and lips, but as skin ages, its levels decrease, resulting in a loss of volume, skin elasticity, and the appearance of wrinkles. There are many forms of hyaluronic acids, most of which have little to no side effects, making them extremely popular. It is superior in that is undergoes isovolumetric degradation (it maintains its volume during the break down process by recruiting water, until it is fully resorbed). These fillers typically last between 4 and 6 months. Captique’s duration appears to be closer to 3 months. Hylaform (Hylaform Regular, Plus, Finelines) is another hyaluronic acid filler derived from rooster combs.

Juvederm recently approved by the FDA is a “next generation” dermal filler, a synthetic gel made of hyaluronic acid. The injection process takes a quick 15 minutes and results are immediate, with minimal recovery time. Juvederm provides the highest concentration of cross-linked HA available, making it an ideal filler to smooth away facial wrinkles and folds, like nasolabial folds (smile lines) around the mouth. It is most effective in this “lower third” of the face. Interestingly, Juvederm is the first FDA approved hyaluronic acid filler proven safe and effective for persons of color.

Restylane and Perlane are non-animal HA produced from a purified and stabilized streptococcus bacterium. These fillers can be used successfully to treat moderate to severe facial wrinkles and folds (around the nose, between brows) and can also be used to create volume (in lips). Injected into the skin below the wrinkle, it literally lifts the wrinkle out to the desired correction. Results are immediate and can last up to 6 months with 1 in 2,000 individuals having any type of allergic reaction. Perlane is a larger molecule than Restylane and therefore does last longer, but has a slightly higher chance of lumpiness.

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